AO Research Award Recipients

2020 Osseointegration Foundation Applied Science Research Grant Presentation

Characterization of Markers from Saliva and Peri-implant Crevicular Fluid in Osteoporotic Patients Receiving a Dental Implant. An Exploratory Study

Elena Calciolari, DDS, MS(Perio), PhD

Currently, the diagnosis of peri-implant diseases and the monitoring of peri-implant health are mainly based on clinical parameters, such as visual inspection of signs of inflammation, bleeding on probing and/or suppuration, probing depth and radiographic marginal bone level. Such clinical criteria present, however, significant limitations and can often have limited sensitivity. In recent years, markers identified in the saliva and peri-implant crevicular fluid (PICF) have attracted growing interest for the possibility to predict implant-related outcomes. This lecture will present the data from an exploratory study that investigated the use of proteins expressed in saliva and PICF (including exosomes) to predict different clinically relevant implant-related outcomes in a population of osteoporotic patients receiving a dental implant.

2019 Osseointegration Foundation Applied Science Research Grant Presentation

Using Digital Implant Planning in Assessing Outcomes of Maxillary Sinus Augmentation Procedures: A Retrospective Study

Irina Dragan, DDS, MS, Tufts University

The aim of this retrospective study was to use digital implant planning and assess radiographic outcomes of maxillary sinus augmentation procedures (ideal bone graft, excess bone graft, and insufficient bone graft) in reference to three-dimensional prosthetic-driven implant placement. The majority of the outcomes highlight an excess in bone grafting during the maxillary sinus elevation. The implant digital planning prior to maxillary sinus elevation can facilitate a better understanding of the expected clinical result. With the use of technology, we can leverage not only reviewing the anatomy of the sinus but quantifying the precise amount of bone graft needed for an adequate site development for future implant placement. This can be achieved only by the collaboration of the interdisciplinary team (surgical-restorative), than have a direct impact on the patient care: time of healing and the cost of the procedure.

2021 Basic Science Research Grant

A Novel Growth Factor-free Adhesive Hydrogel Delivery System for Enhanced Bone Tissue Engineering Applications

Sahar Ansari, MSc, PhD

In the US over a million bone reconstructive procedures are performed due to injury, surgical removal of diseased tissue or congenital defects, representing substantial morbidity, pain and disability toll on the society. Furthermore, this induces major social and economic hurdles, as bone regeneration therapies represent a cost of more than $2.5 billion in the U.S. each year alone. To treat patients, clinicians are often faced with a challenging task of harvesting and grafting in order to recreate the necessary tissue architecture and function. These complex procedures commonly fail to deliver consistent benefits and often result in complications. Thus, a new paradigm for the treatment of damaged bone tissue is needed that can provide effective, and long-term therapy for most patients. Delivery of mesenchymal stromal cells (MSCs) such as gingival mesenchymal stem cells (GMSCs) presents an advantageous therapeutic option for bone tissue engineering, due to the accelerated tissue repairing rates. However, the major drawbacks of the current cell-laden biomaterials for cell delivery applications are low adhesion to the surrounding tissues, lack of suitable mechanical strength, uncontrolled degradation rate, and absence of tissue regenerative properties.

In this research project, we developed an adhesive osteoconductive hydrogel delivery system with the ability to direct human gingival mesenchymal stem cells (GMSCs) toward osteogenesis. The hydrogel biomaterial contains bioceramic microparticles with bone regeneration capacity. We have shown that our engineered adhesive biocomposite are highly osteoconductive, osteoinductive, and able to promote osteogenesis and downregulate osteoclastogenesis in vivo. This accomplishment has been a paradigm shift in engineering bone tissues towards their use in treating maxillofacial and skeletal bone defects and disorders to provide an effective and innovative treatment modality for bone regenerative therapies.

2020 Basic Science Research Grant

Effect of Drilling Preparation on the Cortical Bone Around Implants Subjected to Immediate Mechanical Load

Michele Stocchero, DDS, PhD

When implants are subjected to immediate load, the bone-implant interface is challenged. The implant anchorage is expected to withstand such load and implant primary stability is considered as a pre-requisite for a successful immediate loading protocol. A commonly used strategy to increase the initial implant stability is undersized preparation. This procedure, however, may generate excessive pressure and a major extent of remodelling, which could decrease the implant stability during the healing phase. Contrarily, implants placed with a non-undersized preparation observe an eventual increase of stability with time, but on the other hand they may not exhibit sufficient primary stability.

With this in vivo experiment we simulated immediate occlusal load to implants placed after two different drilling protocols. Thanks to this methodology we evaluated the implant osseointegration and implant stability after 5 weeks of loading.

2021 William R. Laney Award

The Effect of Crown-to-Implant Ratio on the Clinical Outcomes of Dental Implants: A Systematic Review

Andrea Ravida, DDS, MS

The purpose of this study was to investigate the effect of C/I ratio (clinical and anatomical) on implant survival, marginal bone loss, and prosthetic complications. Systematic electronic and manual search was conducted to include clinical trials with a minimum follow-up of 1 year. In total, 15 articles were included in the final analysis. Linear regression analysis did not reveal a significant correlation between anatomical C/I ratios and survival rate, marginal bone loss, or prosthetic complications. Similarly, no significant correlation was observed in the articles providing the clinical C/I ratios. In conclusion, Increased C/I ratio does not seem to be directly related with increased marginal bone loss and does not represent a biomechanical risk factor for the stability of the prosthesis and for the survival of dental implants.

2020 William R. Laney Award

The Effect of Moderately Controlled Type 2 Diabetes on Dental Implant Survival and Peri-implant

Bone Loss: A Long-Term Retrospective Study

Zeev Ormianer, DMD

Diabetes mellitus (DM) is a metabolic disorder, a part of a group of metabolic diseases which influences the patient’s healthstatus. A common complication that is associated with DM, especially DM type 2 (DMT2), is advanced periodontal disease. The prevalence of the periodontal disease is much higher in patients with DMT2 than people without the disease. In addition, the loss of periodontal attachment and alveolar bone starts in early stages of life in such patients compared to general population. One of the main diagnosis of DM is according to HbA1C values. HbA1C < 5.7% is defined as normal and patients with 5.7%Supported by a grant from Quintessence Publishing Co., Inc.